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THE QUESTIONS THAT STUMP THE SCIENTISTS CONES AND CALORIES

THOMAS HAYDEN
Newsweek; U.S. Edition - January 19, 1998

WE'VE COME TO ``the end of science,'' writer John Horgan declared recently, saying that all the really important discoveries have already been made. Stung in their job prospects, scientists quickly responded with lists of what they don't know. After all, somewhere between the big unanswerables like the meaning of life and the specialized esoterica of most doctoral theses--the biogeochemical implications of zooplankton fecal-pellet formation, say, or the evolution of sexual dimorphism in the South American capybara--there must be some questions left that are both important and answerable. More than 30,000 future scientists start out in American Ph.D. programs each year, and they'll need more than a few mysteries to solve. An informal survey of young scientists in a variety of fields turned up some topics that might be worth a look:

Brain teaser: We may never fully understand the human brain, but that doesn't keep researchers from trying. The trick is that you have to use the brain to understand itself, and this can get you caught in horrible self-referential loops. ``It's an awful existential situation to be able to ask the hard questions without the ability to ever answer them,'' laments Bill DeCoteau, a neurobiology grad student at the University of Utah. ``The biology is pretty well understood,'' he says, ``but how does biology get us pride, jealousy, love, hope and all that crap?'' How indeed.

Memory: ``The big Kahuna is `how is knowledge represented in the human brain?' '' says Sarah Schuster, who studies neuroscience at USC. The brain is a physical organ, so the memories it stores must have a physical basis. We haven't found it yet, but if we do, the repercussions will be seismic. Start with the possibility that memories could be isolated, tinkered with or transferred from person to person. Now see how many handy technologies and terrifying sci-fi scenarios you can come up with.

High-temperature superconductors: Resistance (friction for electrons) is an unavoidable hassle for electrical devices--except for when it isn't. Superconductors are materials that allow electricity to flow through them unimpeded, a kind of electronic perpetual motion. Once thought to occur only at the outrageously cold temperatures near absolute zero, the discovery of superconductivity at relatively balmy temperatures (as warm as -200 degrees Fahrenheit) was worth a Nobel Prize. But a decade later, there still isn't a theory that can explain why it happens. ``Every tool known to solid-state physics has been brought to bear on this problem,'' says Doug Bonn, a physics professor at the University of British Columbia. Technical applications are already on the way, but the lack of a solid theory is holding things up.

Turbulence: For all we've learned about weather and the atmosphere, we still don't know much about clear-air turbulence--the kind of violent air motion that blind-sided United Airlines Flight 826 last month. Unlike the convective turbulence kicked up by thunderclouds, clear-air turbulence is almost impossible to detect or predict. Scores of people are injured by turbulence each year. Finding a way to detect and avoid it would make the skies much friendlier.

Missing matter: Simply put, we can't find most of the universe. Physicists have calculated what its total mass should be, and that number is about 10 times what we've been able to observe. Either the equations are wrong or there are entire new classes of matter we haven't found yet. Either way, it'll make for a lot of textbook revisions.

Are we alone? It's a simple yes or no question. Statistically, there's every likelihood that life has evolved elsewhere in the universe. We're still waiting for the first shred of hard evidence of extraterrestrial life. A key question: would we know it if we saw it?

Most scientists will cheerfully admit that what they do know isn't much compared to what they don't. Could the end of scientific discovery really be nigh? No way, says UBC's Bonn. ``I'm just getting started!''

Is frozen yogurt losing its cool? By 2000, sales may drop by 25 percent as waist-watchers shift to low-fat ice creams.

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